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Four genetic loci have been identified as contributing to Alzheimers disease(AD),including the amyloid precursor protein gene,the presenilin 1 gene,the presenlin 2 gene,and the apolipoprotein E gene,but do not account for all the genetic risk for AD.A complete genomic screen in families affected with late-onset AD identified 4 regions of interest after follow- up.Chromosome 12 gave the strongest and most consistent results with a peak multipoint MLS of 3.5,suggesting that this region contains a new susceptibility gene for AD.Additional analyses are necessary to identify the chromosome 12 susceptibility gene for AD and to follow up the regions of interest on chromosomes 4,6,and 20. |
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